The r esear ch on integ rated contr ol of antibiot ic pr oduct ion pro cess inv olves manipula ting the informatio n abo ut pr oduct ion pro cess, m arket info rmat ion, management info rmat ion and experimental data . The key subjects o f computer int egr ated contr ol ar e discussed, including dat a r eco nciliatio n, data mining , optimal contr ol and o pt imal management to impr ove a ntibiot ic pr oduct ion and fermentat ion pro cess.