|Table of Contents|

The Spring of Life Science(PDF)

南京师范大学学报（工程技术版）[ISSN:1006-6977/CN:61-1281/TN]

Issue:
2001年02期
Page:
1-11
Research Field:
Publishing date:

Info

Title:
The Spring of Life Science
Author(s):
Shan Xiangnian
Medical College of Southeast University,Nanjing,210009,PRC
Keywords:
HGP;  Post -genome pr oject;  pharmacoge nomics;  Comparativ e g enomics
PACS:
Q789
DOI:
-
Abstract:
Owing to the joint effor t, by Chinese, American, English, Fr ench, Japanese and German scient ists, Genetic and phy sical maps as w ell as sequence map have been completed t he June of 2000 by HGP started in 1990. A preliminary analy sis has also been made by HGP that human g enome consists of 316. 74M b and 30 to 40 thousand structur al genes. It declar es both the accomplishment o f human structural genomics and the beg inning of post -genomic project , i. e. functional genomics. Scient ists are now wor king har d to r ev ealing the mysteries of humanps bir th, ag e, illness, and death.
First many changes have taken place in the m edical field driv en and pr ompted by HGP. Gene diag nosis, g ene therapy , g ene pharmacy, and pharmaceutical g enomics have penetr ated every corner o f medicine. It w ill be a common clinical practice t o diagnose and cur e humanps disease by molecular biolog y . T he dream that human can dominate his ow n fate w ill come true and people will live a much longer and healt hier life.
Compar ative g enomics is anot her field w hich benefits a lot fr om HGPps smooth oper ation and success. So far there are mor e than 200 species for which genetic and physical maps have been draw n with differ ent precision. The w hole genomic sequencing and co don translation hav e been accomplished fo r some of them, especially the eco nom ical animals and plants closely linked w ith hum anps life. The com pletio n of the animals and plantps genomic pr oject w ill prov ide mo lecular bases and methods for culturing breeds with top quality and high pr oduction. At the same time, w ith the pro gress of comparativ e genomics som e do ubts concerning bilolg ical sor ting and evolution w ill be so lved.
The dev elopment of science and technolog y w hich gives fir st place to life science has been g randly presented to public. I t is peopleps objective to make our countr y prosperous by biological industry . T he tw enty-first centur y is the century o f life science, and the spring of life science w ill inspir e ever y one engaged in life science resear ch to forg e ahead, g ive full play to his t alent and meet the futureps challenges.

References:

[ 1] 贺林. 解码生命[M ] . 北京: 科学出版社, 2000
[ 2] 杨焕明. 生命大解密[M ] . 北京: 中国青年出版社, 2000
[ 3] 于军, 杨焕明. 关于我国人类基因组计划策略性发展的几点意见[ J] . 遗传, 1998, 20( 6) : 1～5
[ 4] 陈竺, 张思仲. 我国人类基因组研究面临的机遇与挑战[ J] . 中华医学遗传学杂志, 1998, 15( 4) : 195～197
[ 5] Collins F, Galas D. A new five-year plan for U. S Human Genome pr oject 1998- 2003[ J] . Science, 1998,282: 682～698
[ 6] Fields C, Adams D. How many genes in the human genome[ J] . Natur e Genetics, 1994, 7: 345
[ 7] Hieter P Bo guski M. Functional genomics: it’s all how y ou r ead it [ J] . Science, 1997, 278( 5338) : 601～602
[ 8] Miklos G L, Rubin G M. T he role o f the genome pr oject in determining gene function: insig hts fr om model or ganisms[ J] . Cell, 1996, 86( 4) : 521～529
[ 9] Pennisi E. NRC Oks long-delay ed sur vey of human genome div ersity[ J] . Science, 1997, 278( 5338) : 568
[ 10] Row en L, Mahairas G, Hoo d L. Sequence of the human g enome[ J] . Science, 1997, 278( 5338) : 605～607
[ 11] Schuler G D. A g ene map o f the human genome[ J] . Science, 1996, 274( 5287) : 540～546
[ 12] Weber J L, Myer s E W. Human w ho le-g enome sho tgun sequencing[ J] . Genom e Res, 1997, 7: 401～409
[ 13] Bar bujani. Appo rtionment of human DNA diver sity [ J] . Pr oc Natl Acad Sci 1997, 94: 4516
[ 14] O Brien, S J. T he promise of compar ative g enomics in mammals[ J] . Science, 1999, 286: 458～481
[ 15] Dean M . Polymor phism Admix ture T yping in Human Et hnic population[ J] . Am J Hum Gent , 1994, 55( 4) :788～808
[ 16] Corder E H. Gene dose of apolipoprotein E type 4 allele and the r isk of Alzheimer’s disease in late onset families Science[ J] . 1993, 261( 5123) : 921～923
[ 17] Ho usman D Ledley F D.Why a pharm acog enomics? Why now [ J] . Nat Biotechnolog y, 1998, 16: 492～493
[ 18] Marshall A. Genset-Abbett deal her alds pharmacog enomics era [ J] . Nat Biotechnolog y, 1997, 15: 829～830
[ 19] Patr ick W. Genetic v ariation as a Guide to Druag Dev elopment[ J] . Science, 1998, 281: 1820～1821
[ 20] Brenner S. Characterizatio n of the pufferfish( Fug u) genome as a compact m odel ver tebrate genome [ J] .Natur e, 1993, 366( 6452) : 265～268
[ 21] Bult C T . Complete g enome sequence of the methanog enic archaeo n, Methano coccus jannaschii[ J] . Science,1998, 273( 5278) : 1058～1073
[ 22] Copeland N G. A genetic linkag e map of the mouse: current application and futur e pr ospects[ J] . Science,1993. 262( 5130) : 57～66
[ 23] DeBr y R W. Human/ mouse homology relationships[ J] . Genomics, 1996, 33( 3) : 337～351
[ 24] Ecker V R. Genome sequencing , Genes blosson from a weed[ J] . Nature, 1998 , 39( 6666) : 438～439
[ 25] Huy nen M A. Different ial g enome display [ J] . Trends Genet, 1997, 13( 10) : 389～390
[ 26] Judson H F. The Eig hth Day of Cr eat ion: M aker s o f the Rev elution in Biolo gy [ M ] . 1998, Ex pandel Edition. New York cold Spr ing Harbor Laborato ry press.
[ 27] Kappes S M . A second-gener ation linkag e m ap of the bo vine genome[ J] . Genome Res, 1997, 7( 3) : 235～249
[ 28] Konin E V. Prokar yotic genomics: the emerg ing parodigm of g enome-based microbiology [ J] . Curr Opin Genet Dev, 1997, 7( 6) : 757～763
[ 29] Ly ons L A. Compar ative ancho r tag ged sequences for integ rativ e mapping of mammalian genomes[ J] .Natur e Genet, 1997, 15( 1) : 47～56
[ 30] McQueen H A. CpG islands of chicken one concer trated on microchromo somes [ J] . Nat Genet, 1996, 12( 3) : 321～324
[ 31] Mckusick V. Genomics: structur al and functional studies of genomes[ J] . Genomics, 1997, 45( 2) : 244～249
[ 32] Pennisi E. Genomics data shake tree of life[ J] . Science, 1998, 280( 5364) : 672～674
[ 33] E S For ce A. Ver tebr ate g enome evolutio n and the Zebrafish g ene map[ J] . Nat Genet, 1998, 18( 4) : 345～349
[ 34] Sasaki T . He Japanese r ice g enome r esearch pr ogr am[ J] . Genome Res, 1996, 6( 8) : 661～666
[ 35] 单祥年. 临床基因诊断[M] . 南京: 南京师范大学出版社, 1999

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Last Update: 2013-04-29