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Research on a New Techonology of Synthesis of L-PhenylalanineBenzyl Ester Hydrochloride(PDF)

南京师范大学学报（工程技术版）[ISSN:1006-6977/CN:61-1281/TN]

Issue:
2015年03期
Page:
80-
Research Field:
化学工程
Publishing date:

Info

Title:
Research on a New Techonology of Synthesis of L-PhenylalanineBenzyl Ester Hydrochloride
Author(s):
Wang Yuqin1; 2
（1.Genchem & Genpharm（Changzhou）
Co.，Ltd.，Changzhou 213127，China）
（Polypeptide Drug and Their Derivatives Engineering Research Center of Jiangsu Province，Changzhou 213127，China）
Keywords:
L-Phenylalanine benzyl ester hydrochloride; L-Phenylalanine; synthesis
PACS:
O625.5
DOI:
-
Abstract:
The paper proposes a new technology line to synthesize L-Phenylalanine benzyl ester hydrochloride. L-Phenylalanine benzyl ester hydrochloride is synthesized from L-phenylalalanine via tert-butoxycarbonylation of amino with di-tert-butyl dicarbonate，condensation with benzyl chloride，and deprotection with hydrochloride solution in ethyl acetate. Through the experiments，the effects of such technology conditions as reaction temperatures，ingredients ratios，acid-binding agents and solvents on the synthesis are explored. The experimental results show that under the optimized techonological conditions，the overall yield of target product is 90.8%，and thus a new option is provided for the synthesis of L-Phenylalanine Benzyl Ester Hydrochloride.

References:

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Memo

Memo:
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Last Update: 2015-09-20