[1]刘 超,江慧玲,王鸿飞,等.生物与化学转化黄芩苷为黄芩素的研究[J].南京师范大学学报(工程技术版),2021,21(04):056-60.[doi:10.3969/j.issn.1672-1292.2021.04.009]
 Liu Chao,Jiang Huiling,Wang Hongfei,et al.Study on Biological and Chemical Transformation of Baicalin into Baicalein[J].Journal of Nanjing Normal University(Engineering and Technology),2021,21(04):056-60.[doi:10.3969/j.issn.1672-1292.2021.04.009]
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生物与化学转化黄芩苷为黄芩素的研究
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南京师范大学学报(工程技术版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
21卷
期数:
2021年04期
页码:
056-60
栏目:
食品科学与工程
出版日期:
2021-12-15

文章信息/Info

Title:
Study on Biological and Chemical Transformation of Baicalin into Baicalein
文章编号:
1672-1292(2021)04-0056-05
作者:
刘 超1江慧玲2王鸿飞2巴塔拿1奥斯曼·科拉3罗海波1陈育如1
(1.南京师范大学食品与制药工程学院,江苏 南京 210023)(2.南京师范大学江苏省微生物与功能基因组学重点实验室,江苏省微生物资源产业化工程技术研究中心,江苏 南京 210023)(3.阿达纳阿尔帕斯兰科技大学工程学院,土耳其 阿达纳 01180)
Author(s):
Liu Chao1Jiang Huiling2Wang Hongfei2Mohamed Hawali Bata Gouda1Osman Kola3Luo Haibo1Chen Yuru1
(1.School of Food Science and Pharmaceutical Engineering,Nanjing Normal University,Nanjing 210023,China)(2.Jiangsu Key Laboratory for Microbes and Functional Genomics,Jiangsu Engineering and Technology Research Center forIndustrialization of Microbial Resources,Nanjing Normal University,Nanjing 210023,China)(3.Faculty of Engineering,Adana Alparslan Türkes Science and Technology University,Adana 01180,Turky)
关键词:
黄芩黄芩素黄芩苷生物转化化学转化
Keywords:
Scutellaria baicalensisbaicaleinbaicalinbiotransformationchemical transformation
分类号:
TS201.3
DOI:
10.3969/j.issn.1672-1292.2021.04.009
文献标志码:
A
摘要:
研究了对黄芩根和黄芩茎叶成份的分析和转化,用生物与化学转化方法将黄芩苷转化为黄芩素. 研究发现,生物转化中黑曲霉效果最佳,黄芩苷转化率为89.5%,黄芩素得率为85.8%. 化学酸水解法得到黄芩苷转化率为98.3%,黄芩素得率为51.6%,比传统的直接酸水解法转化率提高了6.2%,简化了酸水解过程,实验重现性更好. 虽然化学转化的转化率略高于生物转化,但生物转化的得率远高于化学转化,且成本更低,过程中无需强酸,对于环境更为友好,绿色安全.
Abstract:
Scutellaria baicalensis,a valuable herb with plentiful flavonoid,root is mainly used as medicine in traditional Chinese medicine. In this paper,the analysis and transformation of components of Scutellaria baicalensis’ roots and stems and leaves are studied. The biological and chemical methods are selected to convert baicalin into baicalein. The results show that Aspergillus Niger has the best biotransformation effect with 89.5% of baicalin conversion rate,while the yield of baicalein is 85.8%. Meanwhile,the conversion rate of baicalin and baicalein are 98.3% and 51.6% by chemical acid hydrolysis,respectively. In addition,the conversion rate of the acid hydrolysis method and the traditional direct acid hydro-lysis method is increased by 6.2%,and the whole process of acid hydrolysis is simplified,which makes it easier to control and the experiment reproducibility is better. These results indicate that although the conversion rate of chemical transformation is slightly higher than that of biotransformation,the yield of biotransformation is much higher than that of chemical transformation,and the cost is lower; no strong acid is needed in the process,which is friendlier to the environment and green and safe. The results of this investigation also provide technical basis for the industrial production of baicalein.

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备注/Memo

备注/Memo:
收稿日期:2021-06-09.
基金项目:江苏省农业科技自主创新资金项目(CX(20)3176)、江苏省政策引导类计划项目(BX2019014).
通讯作者:陈育如,博士,教授,研究方向:植物天然产物与药物. E-mail:chenyuru@njnu.edu.cn
更新日期/Last Update: 2021-12-15