|Table of Contents|

Study on Synthesis of Isocoumarins and its Evolution(PDF)

南京师范大学学报(工程技术版)[ISSN:1006-6977/CN:61-1281/TN]

Issue:
2005年02期
Page:
64-67
Research Field:
Publishing date:

Info

Title:
Study on Synthesis of Isocoumarins and its Evolution
Author(s):
LI Li YANG Jinfei YUAN Xiangai
School of Chemistry and Environment Science, Nanjing Normal University, Jiangsu Nanjing 210097, China
Keywords:
isocoum arin synthes is bioactiv ity
PACS:
TQ28
DOI:
-
Abstract:
The article introduces the anti-tumo r and o ther pharm aco log ic effec ts o f the isocoum ar ins, rev iews the m ethods of synthesizing isocoum arins, and places an em phasis on introducing and compar ing such m ethods of synthe-sizing syntheticroutes o f d ihydroisocoum arins as ozone ox idation, o rganic m eta l sythes is, cata ly tic ox idation and so on. The article a lso m akes a pre lim inary investigation of the synthesis of po ly subtituedisocoum arin, and finally sug- g ests an expec tation for its prospect in phy sio log ical and bio log ica l activ ity.

References:

[ 1] Roger D B. Isocouma rins developm ent since 1950 [ J]. Chem Rev, 1964, 64( 3): 229.
[ 2] Furuta Takuya. Isocoum arin der ivatives[ P] . JP Pa tent: JP 60142976, 1985-07-29.
[ 3] My ataRyo ich,i Yo sh iokaTakeo. Prepara tion. of anticancer isocouma rins[ P]. JP Patent: JP 0597841, 1993-04-20.
[ 4] H emm i Ke ij.i B iochem istry[ J]. J Org Chem, 1985, 24 ( 8): 1841.
[ 5] Kenda ll JK, F isherT H, SchultzH P. An improved syn- thesis of 6, 8-d ime thoxy-3-m ethy lisocoum arin a funga lm e- tabo lite precursor[ J]. J Org Chem, 1989, 54( 17): 4218- 4220.
[ 6] Laro ck R C, Varaprath S. Synthesis o f isocoum arins v ia thalla tion-o lefination of arenas [ P ] . US Patent: US4650881, 1987-03-17.
[ 7] Brahmbhatt D I. App lication of ortho-lith iation reaction. synthes is of som e 3-ethy l-3, 4-dihydro isocum arins [ J] . J Indian Chem Soc, 1989, 66( 7): 481 -482.
[ 8] Bhide B H, Ako lkar V D, Brahm bhatt D I. Synthesis o f som em elle in der iva tives[ J]. Ind ian J Chem, 1992, 31B ( 2): 116 -117.
[ 9] Ba lavo ineG, E skena ziC, M eun ier F. Cata ly tic ox idation of e thers by theruthen ium ( III) chlor ide /sod ium hypoch lo- r ite system [ J]. JM o l Cata,l 1985, 30( 1~ 2): 125 -133.
[ 10] Nakayam a Kou ich,i H am am oto M asa to sh,i N ishiyam a Yutaka, et al. Ox ida tion o f benzy lic der iva tives w ith d ioxygen catalyzed by m ixed addenda m eta llophospha te conta in ing vanad ium and mo lybdenum [ J]. Chem Le tt, 1993, ( 10): 1699 -1702.
[ 11] S inha N K, Sahay L K, Prasad K, et a l. Synthesis o f som e new 3-e thy l-and 3-pheny lisocouma rins. Ind ian [ J] . JH e tereo C yel Chem, 1992, 1( 5): 235 -240.
[ 12] 袁斌, 袁世平, 徐凛然, 等. 天然物3-甲基-3. 4-二氢异香豆素的合成[ J]. 哈尔滨理工大学学报, 1998, 3 ( 1): 113- 115.
[ 13] 闫福林. 异香豆素类化合物的合成研究[ J] . 新乡医学院学报, 1995, 12( 3): 217- 219.
[ 14] 美露香株式会社. 制备异香豆素及其中间体的方法 [ P]. JP Pa tent: PCT / JP00 /04371, 2002-12-25.
[ 15] Ba rker J A, Staunton J, W ilkinsonM R. A d iastereo se- lective synthesis o f the polyke tide antibiotic c itrin in u- sing toluene an ion chem istry [ J]. J Chem Soc Perk in- trans I, 1986, ( 12) : 2101- 2109.
[ 16] Kessar S V, GuptaY P, S ingh S. O-To lua te ca rban ions fac ile synthesis of hydrangeno l and phy llodule in [ J]. Indian J Chem, 1993, 32B ( 6) : 668 -669.
[ 17] 阎福林. 多取代异香豆素的合成研究[ J]. 河南师范大学学报(自然科学版) , 1999, 27( 2): 46 -47.
[ 18] Yo sh ioka Takeo, M jyata Ryo ich,i Tone H irosh,i et al. An tibiotic M143-37F11 and its m anufacture and syn- thetic inte rm ed iates [ P ]. JP Patent: JP 04112884, 1992-04-14.
[ 19] M erc ian Co rpo ra tion. Process fo r producing iso coum ar ins and interm ediates for the sam e[ P]. JP Paten t: WO97 / 48693, 2003-04-15.
[ 20] C anedoH L, Aceba l S C, Ga. c iaG D. An titum or iso- coum ar ins[ P]. GE Patent: WO9627594, 1996-09-12.

Memo

Memo:
-
Last Update: 2013-04-29