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Preparation and Characterization of Cross-linked Hyaluronan Hydrogel Films(PDF)

南京师范大学学报（工程技术版）[ISSN:1006-6977/CN:61-1281/TN]

Issue:
2007年01期
Page:
54-58
Research Field:
Publishing date:

Info

Title:
Preparation and Characterization of Cross-linked Hyaluronan Hydrogel Films
Author(s):
Nie Suyun1; 2; Lu Wenqing1; 2; Zou Kongbiao1; 2
1.Jiangsu Engineering Research Center of Bio-Medical Functional Materials,2.School of Chemistry and Environmental Science,Nanjing Normal University,Nanjing 210097,China
Keywords:
cross-linked hya luronan;  film;  intrinsic v iscosity;  w ater uptake ab ility
PACS:
TQ460.1
DOI:
-
Abstract:
H ya luronan ( HA ) w as chem ica lly mod ified w ith ad ipic d ihydrazide ( ADH ), and physicochem ica l proper ties of the d ifferent cross-linked dens ityHA-ADH w ere stud ied. HA-ADH film s w ere prepared w ith a so lvent evapora tion m e thod. A fter cross-link ing, differential scann ing calor im etr ic analysis indicated that m icrostruc ture of the prod uct was obv iously altered. The dr ied film had strong ability ofw ate r uptake, and a h ighly porous ne tw ork structurewas detec ted by scann ing e lectron m icrograph, after the film swe lled in buffer. Intrinsic v iscosity [ η] w as measured w ith viscosity m ethod, and [ η ] ofHA and HA-ADH a re 14. 69 dL /g and 20. 21 dL /g , respective ly. Therew as a notable decrease in so lub ility o fHA-ADH film, compared w ithHA film, which cou ld pro long the reservation tim e o f the po ly m er in v ivo.

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Last Update: 2013-04-29